Breakthrough CRISPR/Cas9 Rat Model Technology

Rat model is defined as the use of animal model for research in biomedical science and psycology. Rats and humans have various similarities such as physiology, similar body organs, similar genetic structure to the humans and often suffer from the same diseases. Hence, it is used by scientists and researchers to study and find cure for diseases, create new products and test the end products before being used on humans. The essential factor for using animal models in research is to model human physiology and function as well as to advance the understanding of human diseases. Thus, such models have been instrumental in achieving this goal and is expected to continue to play an important role.

The concept of lab rat established over 150 years ago when rats were the major animal model for the understanding of human diseases. Rats were the first mammalian species to be cultivated for use in the laboratory. Consequently, most in vivo assays were initially developed and improved in the rat. In 2017, newly developed genetic rat models were created to study Phelan-McDermid syndrome. The syndrome demonstrates severe language delay, high rates of autism, attention deficits and, intellectual disability. These models are considered as one of the best models because of its social ability and enhanced cognitive compared to mice.

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Ingenious targeting laboratory is excited to announce the addition of custom gene-edited rat models via an exciting breakthrough technology. Our unique CRISPR/Cas9 technology utilizing spermatogonial stem cells streamlines the production of rat models with unparalleled speed and accuracy, establishing germline-confirmed rat lines 50 percent faster than other CRISPR technologies allow.

CRISPR technology held significant market share in the year 2018 and is forecasted to expand at an 8.4% CAGR over the forecast period. The demand for CRISPR technology among researchers is due to several factors such as potential reduction in animal usage, cost-effectiveness and time savings. CRISPR technology is further expected to pave the way for large number of new genetic rat models.

According to The National Drug Treatment Monitoring System, from 2018, the number of people being treated for cocaine problems increased by 18% from 2017. With the help of rat model, researchers in the country discovered a new path in the brain that links impulses with habits. Furthermore, scientists also showed that long term addiction to drugs can change the area of the brain called basolateral amygdala which is associated with the link between an emotion and a stimulus.

Leading market players in the industry include Envigo, genOway, Charles River, Horizon Discovery Group plc, Biomere, Transviragen Inc., Janvier Labs, Taconic Biosciences Inc. and Transpogen Biopharmaceutical.

References:

https://www.theinsightpartners.com/reports/rat-model-market

https://www.newswire.com/news/breakthrough-crispr-cas9-rat-model-technology-20004950